The commonly accepted hypothesis set up by Brocher in 1950 that the dy
splasia of the pars interarticularis vertebrae is an essential require
ment for the occurrence of spondylolysis should be thought over in lig
ht of recent findings. Newly published investigations show that distur
bed spinal growth leads to dysplasia of the vertebral arch and to spon
dylolysis. Disturbances that play an important role are biomechanical
stress factors that result from the evolution from a quadripedal to a
bipedal human locomotion as well as stress fractures of the vertebral
pars interarticularis and defects in vertebral maturation in small inf
ants.