ASSIGNMENT OF THE HUMAN CARDIAC SLOW SKELETAL-MUSCLE TROPONIN-C GENE (TNNC1) BETWEEN D3S3118 AND GCT4B10 ON THE SHORT ARM OF CHROMOSOME-3 BY SOMATIC-CELL HYBRID ANALYSIS

Authors
TOWNSEND PJ YACOUB MH BARTON PJR
Citation
Pj. Townsend et al., ASSIGNMENT OF THE HUMAN CARDIAC SLOW SKELETAL-MUSCLE TROPONIN-C GENE (TNNC1) BETWEEN D3S3118 AND GCT4B10 ON THE SHORT ARM OF CHROMOSOME-3 BY SOMATIC-CELL HYBRID ANALYSIS, Annals of Human Genetics, 61, 1997, pp. 375-377
Citations number
14
Categorie Soggetti
Genetics & Heredity
Journal title
Annals of Human Genetics → ACNP
ISSN journal
00034800
Volume
61
Year of publication
1997
Part
4
Pages
375 - 377
Database
ISI
SICI code
0003-4800(1997)61:<375:AOTHCS>2.0.ZU;2-P
Abstract
We have determined the chromosomal location of the human cardiac/slow skeletal muscle troponin C gene (TNNC1) to the short arm of chromosome 3 using somatic cell hybrids. PCR-based analysis of a 'monochromosoma l' hybrid panel identified the presence of the TNNC1 gene on human chr omosome 3 and subsequent analysis of the Genebridge4 radiation hybrid panel located the gene between D3S3118 (7.3cR) and GCT4B10 (4.2cR) wit h a lod score of > 3.0.