DIRECT AND INDIVIDUAL DETERMINATION OF ALPHA-CYCLODEXTRIN, BETA-CYCLODEXTRIN AND GAMMA-CYCLODEXTRIN BY FLOW-INJECTION ANALYSIS ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY

Liquid chromatography/mass spectrometry (LC/MS) has found wide applica tions as a reliable tool for the analysis of biological samples.(1-5) However, despite the fact that MS itself has the ability to identify a nd determine analytes in the presence of interfering substances, flow injection analysis/mass spectrometry (FIA/MS) has seldom been reported for the analysis of mixed components. Therefore, we attempted to demo nstrate the excellent ability of FIA/MS in an individual determination of alpha-, beta- and gamma-cyclodextrins (CDs) in a mixture. The appl ication of the established method to the analysis of commercial food p roducts for beta-CD is also reported.