Maam. Guimaraes et al., ROTAVIRUS AND REOVIRUS INTERACTION WITH MOUSE PERITONEAL RESIDENT PHAGOCYTIC-CELLS, Brazilian journal of medical and biological research, 30(10), 1997, pp. 1187-1190
Rotaviruses and reoviruses are involved in human and animal diseases.
It is known that both viruses penetrate the gastrointestinal tract but
their interaction viith phagocytic cells is unknown. To study this in
teraction, peritoneal resident phagocytic cells were used and rotaviru
s and reovirus replication in peritoneal phagocytic cells was observed
. However, rotavirus replication in these cells led to the production
of defective particles since MA-104 cells inoculated with rotavirus ph
agocytic cell lysate did not show any evidence of virus replication. O
n the basis of these results, we suggest that, although reovirus disse
mination may be helped by these phagocytic cells, these cells may cont
rol rotavirus infection and probably contribute to the prevention of i
ts dissemination.