ENANTIOMERIC SEPARATION OF DINICONAZOLE AND UNICONAZOLE BY CYCLODEXTRIN-MODIFIED MICELLAR ELECTROKINETIC CHROMATOGRAPHY

Enantiomeric separation of the structural analogues diniconazole and u niconazole by cyclodextrin (CD)-modified micellar electrokinetic chrom atography was studied. The effects of the type of CDs, CD concentratio n and other operating parameters on the resolution of the enantiomers were clarified and the addition of an organic modifier to the separati on solution was demonstrated to improve significantly the enantiomeric separation of both compounds. Enantiomeric separation of uniconazole was, in fact, achieved only with the addition of organic modifiers.