GROWTH ARREST OF DMBA-INDUCED MAMMARY CARCINOGENESIS WITH IBUPROFEN TREATMENT IN FEMALE SPRAGUE-DAWLEY RATS

Authors
JOARDER FS ABOUISSA H ROBERTSON FM PARRETT ML ALSHAFIE G HARRIS RE
Citation
Fs. Joarder et al., GROWTH ARREST OF DMBA-INDUCED MAMMARY CARCINOGENESIS WITH IBUPROFEN TREATMENT IN FEMALE SPRAGUE-DAWLEY RATS, Oncology Reports, 4(6), 1997, pp. 1271-1273
Citations number
36
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
4
Issue
6
Year of publication
1997
Pages
1271 - 1273
Database
ISI
SICI code
1021-335X(1997)4:6<1271:GAODMC>2.0.ZU;2-9
Abstract
We examined effects of ibuprofen on the growth and development of DMBA -induced mammary cancers in mature female Sprague-Dawley rats. Ibuprof en was added to the standard diet at approximately 1,000 mg/kg rodent chow, resulting in an average daily dose of 25 mg per day per 0.25 kg rat. After five weeks of ibuprofen treatment, there was a 37% reductio n in tumor volume compared to a 260% increase in the volume of tumors in untreated rats (p<0.001). These results suggest that ibuprofen may have potential in the chemoprevention and treatment of breast cancer.