MOLECULAR ANALYSIS OF UTERINE LEIOMYOMAS USING THE PROBES D7S13(7Q) AND HSPA2(14Q)

Authors
WEDELL B HAVEL G HOGSTROM L MARK J
Citation
B. Wedell et al., MOLECULAR ANALYSIS OF UTERINE LEIOMYOMAS USING THE PROBES D7S13(7Q) AND HSPA2(14Q), Oncology Reports, 4(6), 1997, pp. 1275-1276
Citations number
10
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
4
Issue
6
Year of publication
1997
Pages
1275 - 1276
Database
ISI
SICI code
1021-335X(1997)4:6<1275:MAOULU>2.0.ZU;2-6
Abstract
Human uterine leiomyomas, mostly cytogenetically characterized, were a nalyzed by Southern blotting. The region 7q22.3-q31.2 was analyzed in 54 leiomyomas using the polymorphic probe D7S13. The region 14q22-24 w as investigated in 25 leiomyomas with the probe HSPA2. No evidence of rearrangement or amplification of these DNA-regions was observed. Nor was any loss of polymorphism for the probe D7S13 seen. These, and earl ier negative results, motivate further molecular investigation to unde rstand the mechanisms reflected by recurrent chromosome aberrations in myomas.