LOCAL CEREBRAL BLOOD-FLOW AND GLUCOSE-METABOLISM IN CHRONIC FOCAL ISCHEMIA OF STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT

The relationship between local cerebral blood flow (ICBF) and local ce rebral glucose metabolism (ICGU) at the chronic stage of focal cerebra l ischaemia was assessed in young stroke-prone spontaneously hypertens ive rats (SHRSP) following occlusion of the distal middle cerebral art ery (MCA). On day 7 following this occlusion, ICBF and ICGU were measu red by autoradiographic methods using C-14-iodoantipyrine and C-14-2-d eoxyglucose (2DG), respectively. The infarct was limited to the ipsila teral cerebral cortex. A narrow band of increased uptake of C-14-2DG w as observed in the border zone at the periphery of infarcted areas. Th e ICBF in the ischaemic cortex revealed a graded reduction from the is chaemic centre to the surrounding tissues. A significant reduction in ICGU coupled to CBF was also observed in 4 of 13 selected noninfarcted regions ipsilateral to the MCA occlusion. The ischaemic regions had a significant increase in water content. The region with ischaemic oede ma was limited to a narrow area compared with the findings regarding I CBF and ICGU. The SHRSP strain has more severe cerebral ischaemia, oed ema formation, and metabolic derangement at the chronic stage of focal ischaemia, compared to normo-tensive animals.