HLA-G POLYMORPHISM IN FINNISH COUPLES WITH RECURRENT SPONTANEOUS MISCARRIAGE

HLA-G is a class I major histocompatibility complex gene that is expre ssed in cytotrophoblasts at the materno-fetal interface. It has been s uggested that HLA-G could play a key role in materno-fetal immunologic al interactions during pregnancy To investigate whether there is an as sociation between HLA-G locus and recurrent spontaneous miscarriage, H LA-G alleles were determined by a PCR-RFLP method in 38 couples with r ecurrent spontaneous miscarriage and in 26 random control couples. In this series parental HLA-G sharing, extended HLA-G!A haplotypes and th e frequencies of the HLA-G alleles were similar in the two groups. Thu s, our data suggest that there is no detectable relation between susce ptibility to recurrent spontaneous miscarriage and HLA-G locus.