ANAPLASTIC CARCINOMA SHOWING RHABDOID FEATURES COMBINED WITH MUCINOUSCYSTADENOCARCINOMA OF THE PANCREAS

A 52-year-old Japanese woman presented with complaints of back pain, l oss of appetite, and weight loss; her diagnosis was a mass in the panc reatic tail. A distal pancreatectomy combined with lymph node dissecti on was performed. The tumor measured 10.0 x 9.5 x 8.0 cm and consisted of a cystic mass and a solid area. Histologically, the cystic mass re presented a typical mucinous cystadenocarcinoma, whereas the solid por tion was composed of anaplastic tumor cells with round eosinophilic in tracytoplasmic inclusions, as seen in malignant rhabdoid tumor of the kidney. The hyaline-like intracytoplasmic inclusions were weakly posit ive for periodic acid-Schiff and were resistant to diastase. There was a gradual transition between the mucinous cystadenocarcinoma and the anaplastic carcinoma showing rhabdoid features. Additionally, the tumo r cells of the anaplastic carcinoma were immunoreactive to both epithe lial membrane antigen and vimentin. These findings suggest that the an aplastic carcinoma with rhabdoid features developed from the mucinous cystadenocarcinoma of the pancreas.