Ka. Hayes et al., EARLY SUPPRESSION OF VIREMIA BY ZDV DOES NOT ALTER THE SPREAD OF FELINE IMMUNODEFICIENCY VIRUS-INFECTION IN CATS, Journal of acquired immune deficiency syndromes and human retrovirology, 9(2), 1995, pp. 114-122
Prophylactic zidovudine (ZDV) therapy in feline immunodeficiency virus
(FIV) inoculated cats was evaluated for 12 months postinfection (pi)
and 11 months post drug treatment. Plasma FIV antigenemia was prevente
d in six of six ZDV-treated and none of six untreated cats during the
initial phase of infection. The present study is a continuation of tha
t earlier work. CD4 lymphocyte numbers from ZDV-treated cats were high
er than in the untreated cats. CD8 lymphocytes numbers were maintained
within control limits in the ZDV-treated cats, while they declined in
the untreated cats. Anti-FIV antibody titers were comparable between
the ZDV-treated and the untreated cats. Histologically, lymphoid tissu
es for the untreated and ZDV-treated cats were unremarkable and simila
r to those of the uninfected control cats. Low-level FIV antigen was d
etected by enzyme-linked immunosorbent assay in thymus or lymph node h
omogenates from 3 of 11 cats tested. Polymerase chain reaction analysi
s showed FIV DNA in blood, lymph node, bone marrow, spleen, thymus, an
d brain from FIV-inoculated cats irrespective of ZDV treatment. Theref
ore, while prophylactic ZDV treatment prevented detectable plasma anti
genemia and FIV-induced CD8 lymphocyte decline, it did not slow infect
ion of tissues and blood cells of FIV-inoculated cats.