PHARMACOLOGICAL STUDIES OF THE 2 NEW HYPOGLYCEMIC COMPOUNDS 4-(3-METHYL-5-OXO-2-PYRAZOLIN-1-YL)BENZOIC ACID AND 1-(MESITYLEN-2-SULFONYL)-1H-1,2,4-TRIAZOLE

Authors
ANTONFOS GM GARCIADOMENECH R PEREZGIMENEZ F PERISRIBERA JE GARCIAMARCH FJ SALABERTSALVADOR MT
Citation
Gm. Antonfos et al., PHARMACOLOGICAL STUDIES OF THE 2 NEW HYPOGLYCEMIC COMPOUNDS 4-(3-METHYL-5-OXO-2-PYRAZOLIN-1-YL)BENZOIC ACID AND 1-(MESITYLEN-2-SULFONYL)-1H-1,2,4-TRIAZOLE, Arzneimittel-Forschung, 44-2(7), 1994, pp. 821-826
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
44-2
Issue
7
Year of publication
1994
Pages
821 - 826
Database
ISI
SICI code
0004-4172(1994)44-2:7<821:PSOT2N>2.0.ZU;2-A
Abstract
New compounds showing hypoglycaemic activity have been designed hrough a computer-aided method based on QSAR (quantitative structure activit y relationship) and molecular connectivity. The pharmacological tests carried out on the newly designed compounds demonstrated the existence of notable activity for two of them, namely: 4-(3-methyl-5-oxo-2-pyra zolin-1-yl) benzoic acid (CAS 60875-16-3) and 1-(mesitylen-2-sulfonyl) -1H-1,2,4-triazole (CAS 54230-59-0). Both substances mainly follow a m echanism based on the response to the oral glucose overcharge, decreas ing the glycemia to lower levels as compared with tolbutamide, which i s used as a standard drug, and reaching normal glycaemia at a similar time.