SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME 3-PHENACYL-5-BENZYLIDENE-THIAZOLIDINE-2,4-DIONES

Authors
DELIMA JG PERRISSIN M CHANTEGREL J LUUDUC C ROUSSEAU A NARCISSE G
Citation
Jg. Delima et al., SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME 3-PHENACYL-5-BENZYLIDENE-THIAZOLIDINE-2,4-DIONES, Arzneimittel-Forschung, 44-2(7), 1994, pp. 831-834
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
44-2
Issue
7
Year of publication
1994
Pages
831 - 834
Database
ISI
SICI code
0004-4172(1994)44-2:7<831:SAPEOS>2.0.ZU;2-S
Abstract
The synthesis of 54 3-phenacyl-5-benzylidene-thiazolidine -2,4-diones is reported. Eight of them were tested for anti-oedema, analgesic and anticonvulsant activity. Only one compound showed significant anti-oed ematous and analgesic activity. Three compounds protected against toni c seizures and death.