Ls. Changov et al., SYNTHESIS AND BETA-LACTAMASE INHIBITORY ACTIVITY OF NEW 6-BETA-SULFONAMIDOPENICILLANIC ACIDS, Arzneimittel-Forschung, 44-2(7), 1994, pp. 856-858
New 6 beta-aryl(alkyl) sulfonamidopenicillanic acids and their sulfoxi
des were synthesized by sulfonylation of 6 beta-aminopenicilanic acid
or its beta-sulfoxide with an appropriate sulfonyl chloride. The corre
sponding 6 beta-sulfonamidopenicillanic acids sulfones were prepared b
y oxidation of the sulfoxides with potassium permanganate in aqueous m
edium. The obtained compounds reduced the minimum inhibitory concentra
tions of ampicillin against 8 reference and 7 clinically isolated stra
ins.