SYNTHESIS AND BETA-LACTAMASE INHIBITORY ACTIVITY OF NEW 6-BETA-SULFONAMIDOPENICILLANIC ACIDS

Authors
CHANGOV LS VASSILEVALUKANOVA BK ANGELOVAGALABOVA A PAVLOVA AV SPASSOV SL
Citation
Ls. Changov et al., SYNTHESIS AND BETA-LACTAMASE INHIBITORY ACTIVITY OF NEW 6-BETA-SULFONAMIDOPENICILLANIC ACIDS, Arzneimittel-Forschung, 44-2(7), 1994, pp. 856-858
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
44-2
Issue
7
Year of publication
1994
Pages
856 - 858
Database
ISI
SICI code
0004-4172(1994)44-2:7<856:SABIAO>2.0.ZU;2-8
Abstract
New 6 beta-aryl(alkyl) sulfonamidopenicillanic acids and their sulfoxi des were synthesized by sulfonylation of 6 beta-aminopenicilanic acid or its beta-sulfoxide with an appropriate sulfonyl chloride. The corre sponding 6 beta-sulfonamidopenicillanic acids sulfones were prepared b y oxidation of the sulfoxides with potassium permanganate in aqueous m edium. The obtained compounds reduced the minimum inhibitory concentra tions of ampicillin against 8 reference and 7 clinically isolated stra ins.