SYNTHESIS AND ANTHELMINTIC ACTIVITY OF 3-SUBSTITUTED 5-METHYLTHIO-ISOXAZOLES

Isoxazole derivatives have been shown to possess anti-parasitic activi ty. In the present study, 3-substituted 5-methylthio-isoxazoles were s ynthesized and tested for anthelmintic activity, along with some other isoxazoles which have been reported but not tested earlier. Nine comp ounds (2a, 2b, 2e, 2g, 2u 3a, 3b, 3e and 3f) showed activity against b oth A. ceylanicum and N. dubius in vitro. Twelve compounds (2a, 2b, 2d , 2e, 2f, 2h, 2l, 2n, 2o, 2u, 3d and 3e) showed activity against N. du bius in vivo, a parasite of veterinary importance.