We present the case of a 19-year-old patient who was admitted with a s
ubcutaneous scalp lump associated with bilateral papilloedema. CT demo
nstrated a large heterogeneous vault lesion destroying the right parie
tal bone. The mass was hyperdense and enhanced slightly with contrast.
An important intracranial epidural extension was also demonstrated. T
he mass was completely removed through a parietal craniectomy and hist
ological examination was characteristic for a B-cell non-Hodgkin's lym
phoma. Staging revealed other bony lesions and neoplastic cells were a
lso found in the CSF. Systemic and intrathecal chemotherapy were admin
istered. This report discusses both the clinical differential diagnosi
s of scalp masses and the radiological diagnosis of skull lesions.