POISONING BY SODIUM-CHANNEL BLOCKING-AGENTS

Authors
KOLECKI PF CURRY SC
Citation
Pf. Kolecki et Sc. Curry, POISONING BY SODIUM-CHANNEL BLOCKING-AGENTS, Critical care clinics, 13(4), 1997, pp. 829
Citations number
75
Categorie Soggetti
Emergency Medicine & Critical Care
Journal title
Critical care clinics → ACNP
ISSN journal
07490704
Volume
13
Issue
4
Year of publication
1997
Database
ISI
SICI code
0749-0704(1997)13:4<829:PBSB>2.0.ZU;2-E
Abstract
Poisoning by drugs that block voltage-gated sodium channels produces i ntraventricular conduction defects, myocardial depression, bradycardia , and ventricular arrhythmias. Human and animal reports suggest that h ypertonic sodium bicarbonate may be effective therapy for numerous age nts possessing sodium channel blocking properties, including cocaine, quinidine, procainamide, flecainide, mexiletine, bupivacaine, and othe rs.