Gj. Amabeoku et Ja. Syce, PROPRANOLOL-INDUCED SEIZURES IN MICE - THE ROLE OF NORADRENALINE, Cellular and molecular life sciences, 53(8), 1997, pp. 646-651
The effects of some noradrenergic agents, phenobarbitone, diazepam and
phenytoin on seizures produced by propranolol were investigated in mi
ce. Isoprenaline and DL-threo-3,4-dihydroxyphenylserine (DOPS) effecti
vely antagonized the seizures elicited by propranolol. Pargyline and i
mipramine significantly attenuated propranolol-induced seizures and al
so significantly potentiated the protecting effect of DOPS against the
seizures. alpha-Methyl-p-tyrosine disulfiram and reserpine significan
tly potentiated propranolol-elicited seizures. However, DOPS significa
ntly antagonized the seizure-potentiating effects of alpha-methyl-p-ty
rosine, disulfiram and reserpine. Phenylephrine, clonidine, prazosin,
idazoxan, phenobarbitone, diazepam and phenytoin did not significantly
alter propranolol-induced seizures. These results suggest that propra
nolol-induced seizures in mice may involve a noradrenergic mechanism m
ediated via central beta-adrenoceptors.