HYDROGELS IN ENDOVASCULAR EMBOLIZATION .6. TOXICITY TESTS OF POLY(2-HYDROXYETHYL METHACRYLATE) PARTICLES ON CELL-CULTURES

Authors
HORAK D CERVINKA M PUZA V
Citation
D. Horak et al., HYDROGELS IN ENDOVASCULAR EMBOLIZATION .6. TOXICITY TESTS OF POLY(2-HYDROXYETHYL METHACRYLATE) PARTICLES ON CELL-CULTURES, Biomaterials, 18(20), 1997, pp. 1355-1359
Citations number
17
Categorie Soggetti
Engineering, Biomedical","Materials Science, Biomaterials
Journal title
Biomaterials → ACNP
ISSN journal
01429612
Volume
18
Issue
20
Year of publication
1997
Pages
1355 - 1359
Database
ISI
SICI code
0142-9612(1997)18:20<1355:HIEE.T>2.0.ZU;2-Z
Abstract
Cytotoxicity of poly(2-hydroxyethyl methacrylate) [poly(HEMA)] hydroge l spherical particles, prepared by radical suspension polymerization a nd designed for endovascular occlusion, was studied in vitro on cell c ultures. Testing methods included a direct contact test and extraction test. No inhibition of growth of cells surrounding the poly(HEMA) bea ds and a Very low inhibition of cell viability, only in concentrated e xtracts in long-term contact, were observed. As a result, poly(HEMA) b eads can be considered non-toxic. (C) 1997 Elsevier Science Limited. A ll rights reserved.