D. Horak et al., HYDROGELS IN ENDOVASCULAR EMBOLIZATION .6. TOXICITY TESTS OF POLY(2-HYDROXYETHYL METHACRYLATE) PARTICLES ON CELL-CULTURES, Biomaterials, 18(20), 1997, pp. 1355-1359
Cytotoxicity of poly(2-hydroxyethyl methacrylate) [poly(HEMA)] hydroge
l spherical particles, prepared by radical suspension polymerization a
nd designed for endovascular occlusion, was studied in vitro on cell c
ultures. Testing methods included a direct contact test and extraction
test. No inhibition of growth of cells surrounding the poly(HEMA) bea
ds and a Very low inhibition of cell viability, only in concentrated e
xtracts in long-term contact, were observed. As a result, poly(HEMA) b
eads can be considered non-toxic. (C) 1997 Elsevier Science Limited. A
ll rights reserved.