REACTION OF ANTITUMOR HYDROXYMETHYLACYLFULVENE (HMAF) WITH THIOLS

Authors
MCMORRIS TC YU J ESTES LA KELNER MJ
Citation
Tc. Mcmorris et al., REACTION OF ANTITUMOR HYDROXYMETHYLACYLFULVENE (HMAF) WITH THIOLS, Tetrahedron, 53(43), 1997, pp. 14579-14590
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
43
Year of publication
1997
Pages
14579 - 14590
Database
ISI
SICI code
0040-4020(1997)53:43<14579:ROAH(W>2.0.ZU;2-2
Abstract
Hydroxymethylacylfulvene (HMAF) is a semisynthetic derivative of the t oxic sesquiterpene illudin S. HMAF (also designated MGI-114) has poten t antitumor properties and is currently in clinical trials. It reacts with thiols at neutral and acidic pH forming novel products in which t he primary allylic hydroxyl is displaced by thiol. These derivatives r etain antitumor activity. (C) 1997 Elsevier Science Ltd.