BIFUNCTIONAL ANTITUMOR AGENTS - DERIVATIVES OF PYRROLO[9,10-B]PHENANTHRENE - A DNA INTERCALATIVE DELIVERY TEMPLATE

Authors
JONES GB MATHEWS JE
Citation
Gb. Jones et Je. Mathews, BIFUNCTIONAL ANTITUMOR AGENTS - DERIVATIVES OF PYRROLO[9,10-B]PHENANTHRENE - A DNA INTERCALATIVE DELIVERY TEMPLATE, Tetrahedron, 53(43), 1997, pp. 14599-14614
Citations number
40
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
43
Year of publication
1997
Pages
14599 - 14614
Database
ISI
SICI code
0040-4020(1997)53:43<14599:BAA-DO>2.0.ZU;2-7
Abstract
The preparation and intercalative ability of the pyrrolo[9, 10-b]phena nthrene nucleus is described. Functionalization bf the nucleus was ach ieved using standard indole chemistry. The utility of this template as a DNA intercalating drug delivery system is demonstrated by synthesis of a derived bis-chloroethylamine alkylating system and a hybrid DNA interactive enediyne system. (C) 1997 Elsevier Science Ltd.