NOVEL SYNTHETIC ROUTES TO PNA MONOMERS AND PNA-DNA LINKER MOLECULES

Authors
BREIPOHL G WILL DW PEYMAN A UHLMANN E
Citation
G. Breipohl et al., NOVEL SYNTHETIC ROUTES TO PNA MONOMERS AND PNA-DNA LINKER MOLECULES, Tetrahedron, 53(43), 1997, pp. 14671-14686
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
43
Year of publication
1997
Pages
14671 - 14686
Database
ISI
SICI code
0040-4020(1997)53:43<14671:NSRTPM>2.0.ZU;2-Q
Abstract
Novel methods for the preparation of monomethoxytrityl (Mmt) protected aminoethylglycine building blocks and dimethoxytrityl (Dmt) protected hydroxyethylglycine derivatives useful for the synthesis of polyamide nucleic acids (PNAs) and PNA/DNA chimeras are described. The protecti ng group strategy employed for PNA monomer synthesis produces easily i solable intermediates, minimizes chromatographic purification, and is suitable for large-scale monomer synthesis. (C) 1997 Elsevier Science Ltd.