The care of HIV-infected children is fraught with many bioethical conf
licts and dilemmas that require careful attention if care is to be pro
vided appropriately. Understanding of the interplay of such general pr
inciples as autonomy, nonmaleficence, confidentiality, and veracity he
lps to clarify the nature of specific conflicts. This article addresse
s both general principles and their specific applications to pediatric
patients with HIV infection. It addresses these matters from the poin
ts of view both of patients and parents. It shows why conflict is prac
tically inevitable, and it points the way toward prevention and resolu
tion of conflict. Practical guidelines are provided in relation to the
critical problem of disclosure of diagnosis to the patient.