The practice of pharmaceutical conversion, which encompasses three typ
es of drug interchange (generic, brand, and therapeutic substitution),
is increasing in managed care settings, Pharmaceutical conversion has
numerous implications for managed care organizations, their healthcar
e providers, and their customers. Although drug cost may be a driving
consideration in pharmaceutical conversion, a number of other consider
ations are of equal or greater importance in the decision-making proce
ss and may affect the overall cost of patient care. Among these consid
erations are clinical, psychosocial, and safety issues; patient adhere
nce; patient satisfaction; and legal implications of pharmaceutical co
nversion. Patient-centered care must always remain central to decision
s about pharmaceutical conversion. This article discusses the issues r
elated to, and implications of, pharmaceutical conversion utilizing th
e antihistamine class of drugs as the case situation.