Ng. Kundu et al., PALLADIUM-CATALYZED HETEROANNULATION WITH ACETYLENIC-COMPOUNDS - SYNTHESIS OF BENZOFURANS, Journal of the Chemical Society. Perkin transactions. I, (19), 1997, pp. 2815-2820
A detailed study of the heteroannulation of o-iodophenol with acetylen
ic substrates through palladium-copper catalysis leading to the synthe
sis of the 2-substituted benzofurans 21-29 is reported. An acylic comp
ound 30 has been isolated and proved to be an intermediate in the synt
hesis of the benzofurans. Some of the benzofurans have been transforme
d into biologically active compounds.