FIBRINOLYSIS CHANGES IN NORMAL-PREGNANCY

The aim of this study was to evaluate the changes in fibrinolysis para meters during pregnancy. Normal pregnant women (n = 60) formed the stu dy population. Blood samples were taken in the first, second and third trimester, during delivery and three days after delivery. Fibrinolysi s parameters were estimated using commercial tests. Tissue plasminogen activator, D-dimer and plasminogen activator inhibitors (PAI-I and PA I-2) were determined. Tissue plasminogen activator and D-dimer increas ed after the first trimester and reached maximum levels during deliver y. Plasminogen activator inhibitors type 1 and type 2 were also higher , in particular PAI-2, and reached maximum levels in the third trimest er. On the third day after delivery, fibrinolysis activity recovered, but D-dimer and PAI-2 levels remained above the normal non-pregnant ra nge.