DEVELOPMENTAL-CHANGES IN SERUM IGF-1 AND IGFBP LEVELS AND LIVER IGFBP-3 MESSENGER-RNA EXPRESSION IN INTRAUTERINE GROWTH-RETARDED AND CONTROL SWINE

Authors
KAMPMAN KA RAMSAY TG WHITE ME
Citation
Ka. Kampman et al., DEVELOPMENTAL-CHANGES IN SERUM IGF-1 AND IGFBP LEVELS AND LIVER IGFBP-3 MESSENGER-RNA EXPRESSION IN INTRAUTERINE GROWTH-RETARDED AND CONTROL SWINE, Comparative biochemistry and physiology. B. Comparative biochemistry, 108(3), 1994, pp. 337-347
Citations number
44
Categorie Soggetti
Biology
Journal title
Comparative biochemistry and physiology. B. Comparative biochemistry → ACNP
ISSN journal
03050491
Volume
108
Issue
3
Year of publication
1994
Pages
337 - 347
Database
ISI
SICI code
0305-0491(1994)108:3<337:DISIAI>2.0.ZU;2-7
Abstract
The 29 M(r) x 10(-3) IGFBP was significantly elevated (P < 0.01) in IU GR piglets at 90 days fetally and at birth. Developmentally, 29 M(r) x 10(-3) IGFBP levels were higher fetally and at birth than at 21 and 4 9 days of age (P < 0.05). At 90 days fetally, hepatic IGFBP-3 mRNA lev els were very high, while circulating levels of IGFBP-3 were extremely low whereas postnatally, hepatic IGFBP-3 mRNA and serum IGFBP-3 level s were parallel. This study provides new information concerning the de velopmental expression of IGFBP-3 and the relationship between serum l evels of the 29 M(r) x 10(-3) IGFBP and IUGR in swine.