A FACILE METHOD FOR DETRITYLATION OF L-3'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYNUCLEOSIDES

Authors
PATIL SV MANE RB SALUNKHE MM
Citation
Sv. Patil et al., A FACILE METHOD FOR DETRITYLATION OF L-3'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYNUCLEOSIDES, Synthetic communications, 24(17), 1994, pp. 2423-2428
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
24
Issue
17
Year of publication
1994
Pages
2423 - 2428
Database
ISI
SICI code
0039-7911(1994)24:17<2423:AFMFDO>2.0.ZU;2-P
Abstract
The dimethoxytrityl group can be removed effectively from 5'-O-dimetho xytrityl-3'-O-tert-butyl dimethylsilyl-2'-deoxynucleosides and their N -acyl derivatives by using sulfonated crosslinked (1% DVB) polystyrene in dichloromethane-methanol (97.5 : 2.5, v/v) without causino depurin ation. It has been observed that solvent and percentage of crosslinkin g plays important role in these reactions.