Sv. Patil et al., A FACILE METHOD FOR DETRITYLATION OF L-3'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYNUCLEOSIDES, Synthetic communications, 24(17), 1994, pp. 2423-2428
The dimethoxytrityl group can be removed effectively from 5'-O-dimetho
xytrityl-3'-O-tert-butyl dimethylsilyl-2'-deoxynucleosides and their N
-acyl derivatives by using sulfonated crosslinked (1% DVB) polystyrene
in dichloromethane-methanol (97.5 : 2.5, v/v) without causino depurin
ation. It has been observed that solvent and percentage of crosslinkin
g plays important role in these reactions.