Sv. Kudrevich et al., SYNTHESIS OF OCTACARBOXYTETRA(2,3-PYRAZINO)PORPHYRAZINE - NOVEL WATER-SOLUBLE PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY, Synthesis, (8), 1994, pp. 779-781
The condensation of 2,3-dicyano-5,6-diethoxycarbonylpyrazine with a me
tal salt affords ra-2,3-(5,6-diethoxycarbonylpyrazino)porphyrazine, wh
ich upon mild hydrolysis yields novel water-soluble metal complexes of
tetra-2,3-(5,6-dicarboxypyrazino)porphyrazine. These octaaza analogs
of phthalocyanine have potential applications in the field of photodyn
amic therapy of cancer.