SYNTHESIS OF 2'-ARYLAZABICYCLO-3-SPIRO-4'(5')-IMIDAZOLINES

Authors
WHELAN B IRIEPA I GALVEZ E
Citation
B. Whelan et al., SYNTHESIS OF 2'-ARYLAZABICYCLO-3-SPIRO-4'(5')-IMIDAZOLINES, Synthesis, (8), 1994, pp. 832-836
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
8
Year of publication
1994
Pages
832 - 836
Database
ISI
SICI code
0039-7881(1994):8<832:SO2>2.0.ZU;2-9
Abstract
A method is described for the synthesis of a series of 2'-aryl-3-azabi cyclospiro-4'(5')-imidazolines via the reaction of azabicyclic 1,2-dia mines with aryl imidate salts. Competing reactions in the synthesis of the diamines such as the reduction of amino nitriles with LiA1H(4) le ad to some anomalous products. In the Pinner synthesis, unstable pyrid ine-type imidates were stabilized as their N-oxide derivatives.