SYNTHESIS OF 3-HYDROXYPYRIMIDINE-2,4-DIONES - ADDITION OF ANILINES TOBENZYLOXY ISOCYANATE SYNTHONS TO GIVE N-HYDROXYUREAS

Authors
ROMINE JL MARTIN SW MEANWELL NA EPPERSON JR
Citation
Jl. Romine et al., SYNTHESIS OF 3-HYDROXYPYRIMIDINE-2,4-DIONES - ADDITION OF ANILINES TOBENZYLOXY ISOCYANATE SYNTHONS TO GIVE N-HYDROXYUREAS, Synthesis, (8), 1994, pp. 846-850
Citations number
35
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
8
Year of publication
1994
Pages
846 - 850
Database
ISI
SICI code
0039-7881(1994):8<846:SO3-AO>2.0.ZU;2-C
Abstract
A new method, the addition of N-benzyloxychloroformate to methyl anthr anilate followed by base-catalyzed cyclization, has been employed to s ynthesize the N-hydroxyquinazolinedione 1 and heterocyclic derivatives . N-Benzyloxycarbonylimidazole is a useful synthon to prepare N-hydrox yureas.