SYNTHESIS OF (R)-4-OXO-5-PHOSPHONONORVALINE, AN N-METHYL-D-ASPARTIC ACID RECEPTOR-SELECTIVE BETA-KETO PHOSPHONATE

Authors
RUDISILL DE WHITTEN JP
Citation
De. Rudisill et Jp. Whitten, SYNTHESIS OF (R)-4-OXO-5-PHOSPHONONORVALINE, AN N-METHYL-D-ASPARTIC ACID RECEPTOR-SELECTIVE BETA-KETO PHOSPHONATE, Synthesis, (8), 1994, pp. 851-854
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
8
Year of publication
1994
Pages
851 - 854
Database
ISI
SICI code
0039-7881(1994):8<851:SO(ANA>2.0.ZU;2-E
Abstract
(R)-4-Oxo-5-phosphononorvaline (1), a selective NMDA glutamate site an tagonist, has been synthesized in four steps (overall yield = 31%) fro m (R)-aspartic acid, without racemization.