INFLUENCE OF HIGH-DOSE KETAMINE ON THE VASCULAR REACTIVITY OF HUMAN AND PORCINE ISOLATED CORONARY-ARTERY SEGMENTS

Authors
KLOCKGETHERRADKE A HAGEMANN I FRERICHS A MAJOWSKI K HELLIGE G
Citation
A. Klockgetherradke et al., INFLUENCE OF HIGH-DOSE KETAMINE ON THE VASCULAR REACTIVITY OF HUMAN AND PORCINE ISOLATED CORONARY-ARTERY SEGMENTS, Acta anaesthesiologica Scandinavica, 41(9), 1997, pp. 1200-1203
Citations number
10
Categorie Soggetti
Anesthesiology
Journal title
Acta anaesthesiologica Scandinavica → ACNP
ISSN journal
00015172
Volume
41
Issue
9
Year of publication
1997
Pages
1200 - 1203
Database
ISI
SICI code
0001-5172(1997)41:9<1200:IOHKOT>2.0.ZU;2-B
Abstract
The influence of ketamine on the vasomotor effect of histamine and ser otonin was studied in isolated human and porcine coronary artery rings . Ketamine (10(-3) mol L-1) attenuated the contractile response to bot h mediators significantly (P<0.05 for histamine concentrations of 3x10 (-5) mol L-1 and above as well as for serotonin concentrations of 3x10 (-8) mol L-1 and above). This effect of ketamine was observed in intac t and endothelial denuded porcine rings (difference n.s.) as well as i n coronary arteries from explanted human hearts of patients undergoing heart transplantation. It is concluded that this reduction of the con tractile response to histamine and serotonin caused by ketamine is not dependent on the endothelial function (e.g. endothelium-derived relax ing factor). (C) Acta Anaesthesiologica Scandinavica 41(1997).