A. Klockgetherradke et al., INFLUENCE OF HIGH-DOSE KETAMINE ON THE VASCULAR REACTIVITY OF HUMAN AND PORCINE ISOLATED CORONARY-ARTERY SEGMENTS, Acta anaesthesiologica Scandinavica, 41(9), 1997, pp. 1200-1203
The influence of ketamine on the vasomotor effect of histamine and ser
otonin was studied in isolated human and porcine coronary artery rings
. Ketamine (10(-3) mol L-1) attenuated the contractile response to bot
h mediators significantly (P<0.05 for histamine concentrations of 3x10
(-5) mol L-1 and above as well as for serotonin concentrations of 3x10
(-8) mol L-1 and above). This effect of ketamine was observed in intac
t and endothelial denuded porcine rings (difference n.s.) as well as i
n coronary arteries from explanted human hearts of patients undergoing
heart transplantation. It is concluded that this reduction of the con
tractile response to histamine and serotonin caused by ketamine is not
dependent on the endothelial function (e.g. endothelium-derived relax
ing factor). (C) Acta Anaesthesiologica Scandinavica 41(1997).