LONG-TERM CARVEDILOL THERAPY INCREASES PARASYMPATHETIC NERVOUS-SYSTEMACTIVITY IN CHRONIC CONGESTIVE-HEART-FAILURE

Authors
GOLDSMITH RL BIGGER JT BLOOMFIELD DM KRUM H STEINMAN RC SACKNERBERNSTEIN J PACKER M
Citation
Rl. Goldsmith et al., LONG-TERM CARVEDILOL THERAPY INCREASES PARASYMPATHETIC NERVOUS-SYSTEMACTIVITY IN CHRONIC CONGESTIVE-HEART-FAILURE, The American journal of cardiology, 80(8), 1997, pp. 1101
Citations number
28
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
The American journal of cardiology → ACNP
ISSN journal
00029149
Volume
80
Issue
8
Year of publication
1997
Database
ISI
SICI code
0002-9149(1997)80:8<1101:LCTIPN>2.0.ZU;2-Y
Abstract
To determine the effect of beta blockade on parasympathetic nervous sy stem activity, we assessed RR variability during 24-hour Holter monito ring in 10 patients with congestive heart failure before and after 3 t o 4 months of treatment with the beta blocker carvedilol. High-frequen cy-power increased from 26 to 64 ms(2), root-mean-square of successive differences in RR interval increased from 14.3 to 23.7 ms(2), and per centage of absolute differences >50 ms between successive normal RR in tervals increased from 0.8% to 4.7%, all p <0.01, indicating a substan tial increase in parasympathetic modulation of RR intervals.