A MOLECULAR MODELING ANALYSIS OF THE BINDING INTERACTIONS BETWEEN THEOKADAIC ACID CLASS OF NATURAL PRODUCT INHIBITORS AND THE SER-THR PHOSPHATASES, PP1 AND PP2A

Authors
GAUSS CM SHEPPECK JE NAIRN AC CHAMBERLIN R
Citation
Cm. Gauss et al., A MOLECULAR MODELING ANALYSIS OF THE BINDING INTERACTIONS BETWEEN THEOKADAIC ACID CLASS OF NATURAL PRODUCT INHIBITORS AND THE SER-THR PHOSPHATASES, PP1 AND PP2A, Bioorganic & medicinal chemistry, 5(9), 1997, pp. 1751-1773
Citations number
24
Categorie Soggetti
Biology,"Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
5
Issue
9
Year of publication
1997
Pages
1751 - 1773
Database
ISI
SICI code
0968-0896(1997)5:9<1751:AMMAOT>2.0.ZU;2-5
Abstract
We have proposed computer-generated models of the catalytic subunits o f the serine-threonine protein phosphatases PP1 and PP2A complexed wit h their endogenous substrate phospho-DARPP-32, and several known natur ally occurring inhibitors. This study is part of an overall effort to elucidate the signal transduction pathways in which PP1 and PP2A may p lay an important role. (C) 1997 Published by Elsevier Science Ltd.