LUPUS ANTICOAGULANT AND SNEDDONS-SYNDROME

We present the coagulation and serological studies of four patients wi th Sneddon's syndrome, in which antiphospholipid antibodies (anticardi olipin antibodies and lupus anticoagulant) were determined using cardi olipin and a mixture of phospholipid from rabbit brain as antigen for detection of lupus anticoagulant by ELISA. Our results support a relat ion between Sneddon's syndrome and lupus anticoagulant (IgG subtype) i n all cases. The anticardiolipin antibody test was positive only in tw o cases (one in low level). All patients could be diagnosed as having primary antiphospholipid antibody syndrome. Antiaggregant treatment wa s not effective in preventing thrombosis in two cases. Three of four p atients received long-term oral anticoagulation therapy, with no recur rence of thrombosis observed for a period of at least 3 years.