INHIBITION OF MELANOGENESIS IN B16 MOUSE MELANOMA BY POLYPHENOL-GLUCOSIDES

Authors
FUNAYAMA M ARAKAWA H SAYAMA Y YAMAMOTO R
Citation
M. Funayama et al., INHIBITION OF MELANOGENESIS IN B16 MOUSE MELANOMA BY POLYPHENOL-GLUCOSIDES, Seibutsu kogaku kaishi, 75(5), 1997, pp. 333-337
Citations number
6
Categorie Soggetti
Food Science & Tenology","Biothechnology & Applied Migrobiology
Journal title
Seibutsu kogaku kaishi → ACNP
ISSN journal
09193758
Volume
75
Issue
5
Year of publication
1997
Pages
333 - 337
Database
ISI
SICI code
0919-3758(1997)75:5<333:IOMIBM>2.0.ZU;2-V
Abstract
Phenolic-alpha-glucosides were synthesized from polyphenols and starch using glucoside synthetase or cyclodextringlucanotransferase. The inh ibition of melanogenesis in B16 mouse melanoma by fourteen polyphenol- alpha-glucosides was investigated, among which hydroquinone, and m-and p-coumaric acid derivatives inhibited melanogenesis (18% at 350 mu M, 25% at 5000 mu M, and 70% at 1000 mu M, respectively) without inhibit ion of cell growth. Catechin-alpha-glucoside, which inhibits tyrosinas e activity in mushroom, did not inhibit melanogenesis in mouse melanom a.