NEUTRALIZING ANTIBODY AND CHALLENGE RESPONSE TO LIVE AND INACTIVATED AVIAN ADENOVIRUS-1 IN BROILERS

Immune responses to live and inactivated avian adenovirus-1 were evalu ated in broilers by neutralising antibody response and challenge react ion. The neutralising antibody titre was 1:256, 1:64 and 1:32 in live virus, inactivated virus and uninoculated control birds respectively a t 3 weeks post inoculation when they were challenged. At one week post challenge the antibody titres were 1:941, 1:247 and 1:375 in live vir us, inactivated virus and control birds, respectively. There was a boo ster effect of challenge in the live virus inoculated group up to 3 we eks post challenge. The post challenge histopathological evaluation of liver; kidneys, lungs and bursa revealed less severe changes in the l ive virus inoculated group as compared to other groups.