SKIN BIOPSY AS A NONDESTRUCTIVE TOOL FOR THE TOXICOLOGICAL ASSESSMENTOF ENDANGERED POPULATIONS OF PINNIPEDS - PRELIMINARY-RESULTS ON MIXED-FUNCTION OXIDASE IN OTARIA-FLAVESCENS

Authors
FOSSI MC SAVELLI C MARSILI L CASINI S JIMENEZ B JUNIN M CASTELLO H LORENZANI JA
Citation
Mc. Fossi et al., SKIN BIOPSY AS A NONDESTRUCTIVE TOOL FOR THE TOXICOLOGICAL ASSESSMENTOF ENDANGERED POPULATIONS OF PINNIPEDS - PRELIMINARY-RESULTS ON MIXED-FUNCTION OXIDASE IN OTARIA-FLAVESCENS, Chemosphere, 35(8), 1997, pp. 1623-1635
Citations number
37
Categorie Soggetti
Environmental Sciences
Journal title
Chemosphere → ACNP
ISSN journal
00456535
Volume
35
Issue
8
Year of publication
1997
Pages
1623 - 1635
Database
ISI
SICI code
0045-6535(1997)35:8<1623:SBAANT>2.0.ZU;2-N
Abstract
The aim of this study was to develop and validate a method for assessi ng the toxicological risk of endangered populations of pinnipeds based on a nondestructive biological tool, the skin biopsy specimen. Skin b iopsies can be obtained from pinnipeds by anaesthetising the animals a nd taking a small amount of skin in the anterior flipper area, or by s hooting a biopsy dart with a crossbow. Skin biopsy material is suitabl e for a wide range of chemical and biomarker analysis. Organochlorines and polycyclic aromatic hydrocarbons can be analysed in subcutaneous fat and MFO activity (BPMO), Cyt.P450 isoforms, and DNA damage can be detected in epidermis. (C) 1997 Elsevier Science Ltd.