REDOX REACTIONS OF CHLORAMPHENICOL AND SOME ARYL PEROXYL RADICALS IN AQUEOUS-SOLUTIONS - A PULSE RADIOLYTIC STUDY

Redox reactions of aqueous chloramphenicol (CPL) solutions with H., e( aq)(-), OH., (CH3)(2)(OH)C, and CO2(.-) were studied using pulse radi olysis techniques. Rate constants for the reaction of these radicals w ith CPL were determined. Using MV2+/MV.+ as the standard couple, the o ne-electron redox potential of the CPL was determined. High-performanc e liquid chromatography was employed for the investigation of the degr adation products. The possible formation of aryl radicals from CPL and nitrosobenzoic acid (one of the several products formed In irradiated CPL aqueous solution) and its subsequent reaction with O-2 can lead t o the formation of aryl peroxyl radicals. The reactivity of various p- substituted aryl peroxyl radicals with 2,2'-azinobis(3-ethylbenzothiaz oline-6-sulfonate) (ABTS) was studied. Such a reaction product could b e responsible for observed side effects of CPL.