SUNLIGHT AND THE ONSET OF SKIN-CANCER

Authors
BRASH DE
Citation
De. Brash, SUNLIGHT AND THE ONSET OF SKIN-CANCER, Trends in genetics, 13(10), 1997, pp. 410-414
Citations number
40
Categorie Soggetti
Genetics & Heredity
Journal title
Trends in genetics → ACNP
ISSN journal
01689525
Volume
13
Issue
10
Year of publication
1997
Pages
410 - 414
Database
ISI
SICI code
0168-9525(1997)13:10<410:SATOOS>2.0.ZU;2-Y
Abstract
The photons of sunlight precipitate a series of genetic events in skin leading to cancer. These events involve somatic mutations as well as inherited alleles. Competition between cell populations ensues, as a s ingle mutated cell expands into a clone. Thus cancer involves both a s ingle-cell problem and a many-cell problem; in skin cancer, sunlight a ppears to drive both.