STUDIES OF THE HEPATIC MITOCHONDRIAL AND MICROSOMAL MIXED-FUNCTION OXIDASE SYSTEM DURING PLASMODIUM-YOELII INFECTION AND INDUCER TREATMENT IN SWISS ALBINO MICE

Plasmodium yoelii infection resulted in depression of hepatic mitochon drial and microsomal mixed-function oxidase system indices, e.g. cytoc hrome P-450 cytochrome b5 and phase II detoxification enzyme glutathio ne-S-transferase, while heam and haemozoin registered a marked increas e in Swiss albino mice. Phenobarbitone (inducer) treatment showed indu ced levels of hepatic mitochondrial and microsomal cytochrome P-450 an d glutathione-S-transferase in normal as well as in infected mice. The induced cytochrome P-450 and glutathione-S-transferase activities wer e similar in normal and infected mice. The findings were further suppo rted by the isoenzymic profile and drug-binding properties of the term inal monoxygenase, cytochrome P-450.