X-LINKED SEVERE COMBINED IMMUNODEFICIENCY IN A FAMILY OF CARDIGAN WELSH CORGIS

Two, male, Cardigan Welsh corgi puppies, one of which was diagnosed wi th X-linked severe combined immunodeficiency (XSCID), are described in this report, The first puppy was euthanized before definitive immunol ogical testing could be performed, When the second puppy was presented and the relationship between the two was discovered, immunological te sting was pursued immediately due to this puppy's rapid deterioration, The immunological test results and genetic studies were compared to t he XSCID basset hounds and found to be similar. By unveiling the mutat ion, the pedigree could be analyzed and the carrier females removed fr om the breeding population.