MENIERES-SYNDROME AND MIGRAINE - INCIDENCE IN ONE FAMILY

Since 1992, we have applied a standard questionnaire to all our Menier e's syndrome patients. We ask about other family members affected by t he symptoms and about the presence of the usual migraine symptoms. Thr ough this questionnaire we have identified a family that has some memb ers affected by Meniere's syndrome alone, some others with associated migraine, and still others with migraine alone. Two members of this fa mily started out with migraine and later in life developed Meniere's s yndrome. The genetic transmission follows an autosomal dominant patter n for both Meniere's syndrome and migraine. We have interviewed and st udied 19 affected persons from several generations of this family, who form the basis of this report. The possibility of a common autosomal dominant genetic determinant for Meniere's syndrome and migraine and i ts implications for the causation of Meniere's disease are discussed.