RESPONSES OF HALOBACTERIUM-HALOBIUM AND SULFOLOBUS-SOLFATARICUS TO HYDROGEN-PEROXIDE AND N-METHYL-N-NITROSOGUANIDINE EXPOSURE

Citation
Ca. Praul et Wd. Taylor, RESPONSES OF HALOBACTERIUM-HALOBIUM AND SULFOLOBUS-SOLFATARICUS TO HYDROGEN-PEROXIDE AND N-METHYL-N-NITROSOGUANIDINE EXPOSURE, Microbiological research, 152(3), 1997, pp. 257-260
Citations number
15
Categorie Soggetti
Environmental Sciences",Microbiology
Journal title
ISSN journal
09445013
Volume
152
Issue
3
Year of publication
1997
Pages
257 - 260
Database
ISI
SICI code
0944-5013(1997)152:3<257:ROHAST>2.0.ZU;2-8
Abstract
We have examined the capacity of Halobacterium halobium and Sulfolobus solfataricus to withstand the lethal effects of hydrogen peroxide and N-methyl-N-nitrosoguanidine. We tested a variety of pretreatment regi mens with both mutagens and all failed to elicit an inducible response to the lethal effects of these compounds in either organism. We have observed AP endonuclease activity in protein extracts from both organi sms. In addition, S. solfataricus extracts contain activities that rem ove 3-methyl-adenine and O-6-methyl-guanine from methylated DNA. This is the first report of these DNA repair activities in any member of th e Archaea.