GLUCOKINASE IS LOCATED IN SECRETORY GRANULES OF PANCREATIC D-CELLS

Authors
TOYODA Y YOSHIE S FUJITA T ITO Y NONOGAKI T MIWA I
Citation
Y. Toyoda et al., GLUCOKINASE IS LOCATED IN SECRETORY GRANULES OF PANCREATIC D-CELLS, FEBS letters, 415(3), 1997, pp. 281-284
Citations number
22
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
415
Issue
3
Year of publication
1997
Pages
281 - 284
Database
ISI
SICI code
0014-5793(1997)415:3<281:GILISG>2.0.ZU;2-3
Abstract
We immunohistochemically examined the distribution of glucokinase in r at pancreatic islets. Glucokinase immunoreactivity under light microsc opy was detected in the cytoplasm of somatostatin cells as well as in that of insulin cells. No specific immunoreactivity was detected in gl ucagon and pancreatic polypeptide cells. In somatostatin cells, glucok inase immunoreactivity was located by electron microscopy exclusively within secretory granules. (C) 1997 Federation of European Biochemical Societies.