COMPARISON OF INDUCTIVELY-COUPLED PLASMA-ATOMIC EMISSION-SPECTROMETRYAND INDUCTIVELY-COUPLED PLASMA-MASS SPECTROMETRY WITH QUANTITATIVE NEUTRON-CAPTURE RADIOGRAPHY FOR THE DETERMINATION OF BORON IN BIOLOGICALSAMPLES FROM CANCER-THERAPY

Citation
Tu. Probst et al., COMPARISON OF INDUCTIVELY-COUPLED PLASMA-ATOMIC EMISSION-SPECTROMETRYAND INDUCTIVELY-COUPLED PLASMA-MASS SPECTROMETRY WITH QUANTITATIVE NEUTRON-CAPTURE RADIOGRAPHY FOR THE DETERMINATION OF BORON IN BIOLOGICALSAMPLES FROM CANCER-THERAPY, Journal of analytical atomic spectrometry, 12(10), 1997, pp. 1115-1122
Citations number
70
Categorie Soggetti
Spectroscopy
ISSN journal
02679477
Volume
12
Issue
10
Year of publication
1997
Pages
1115 - 1122
Database
ISI
SICI code
0267-9477(1997)12:10<1115:COIPE>2.0.ZU;2-Q
Abstract
A boron-containing compound was administered to tumor-bearing mice and the time-dependent concentration was determined by ICP-AES, ICP-MS an d quantitative neutron capture radiography (QNCR). The atomic spectrom etric procedures were optimized to minimize analyte losses during micr owave digestion. Non-spectroscopic interferences were investigated in detail and appropriate internal standards were established for ICP-MS. The best detection limits achieved for boron were 30 ng ml(-1) by ICP -AES and 0.3 ng ml(-1) by ICP-MS. The respective determination limits in the digested and diluted tissue samples were 0.4 mu g ml(-1) and 3 ng ml(-1). The results of the spectrometric determinations were confir med by QNCR of whole-body cryosections of six mice, A brief descriptio n of the metabolism of the boron compound is given.