COMPARISON OF INDUCTIVELY-COUPLED PLASMA-ATOMIC EMISSION-SPECTROMETRYAND INDUCTIVELY-COUPLED PLASMA-MASS SPECTROMETRY WITH QUANTITATIVE NEUTRON-CAPTURE RADIOGRAPHY FOR THE DETERMINATION OF BORON IN BIOLOGICALSAMPLES FROM CANCER-THERAPY
Tu. Probst et al., COMPARISON OF INDUCTIVELY-COUPLED PLASMA-ATOMIC EMISSION-SPECTROMETRYAND INDUCTIVELY-COUPLED PLASMA-MASS SPECTROMETRY WITH QUANTITATIVE NEUTRON-CAPTURE RADIOGRAPHY FOR THE DETERMINATION OF BORON IN BIOLOGICALSAMPLES FROM CANCER-THERAPY, Journal of analytical atomic spectrometry, 12(10), 1997, pp. 1115-1122
A boron-containing compound was administered to tumor-bearing mice and
the time-dependent concentration was determined by ICP-AES, ICP-MS an
d quantitative neutron capture radiography (QNCR). The atomic spectrom
etric procedures were optimized to minimize analyte losses during micr
owave digestion. Non-spectroscopic interferences were investigated in
detail and appropriate internal standards were established for ICP-MS.
The best detection limits achieved for boron were 30 ng ml(-1) by ICP
-AES and 0.3 ng ml(-1) by ICP-MS. The respective determination limits
in the digested and diluted tissue samples were 0.4 mu g ml(-1) and 3
ng ml(-1). The results of the spectrometric determinations were confir
med by QNCR of whole-body cryosections of six mice, A brief descriptio
n of the metabolism of the boron compound is given.