DIFFERENTIAL-EFFECTS OF ACUTE ADMINISTRATION OF CLOZAPINE OR HALOPERIDOL ON LOCAL CEREBRAL GLUCOSE-UTILIZATION IN THE RAT

We employed the [C-14]2-deoxyglucose method in order to map local brai n metabolic activity of rats administered 1, 5, or 20 mg/kg of clozapi ne, or 0.5 mg/kg of haloperidol, as compared to saline. Clozapine prod uced a dose-dependent reduction of glucose utilization. At the dose of I mg/kg, the effects were limited to limbic areas. An additional numb er of structures were significantly affected following administration of 5 mg/kg (the whole hippocampal formation and septal area, and corti cal limbic areas). The dose of 20 mg/kg markedly reduced glucose utili zation in most of the areas examined. Haloperidol (0.5 mg/kg) reduced glucose utilization of the orbital cortex, hippocampal formation and s eptal area, globus pallidus, amygdala, ventral thalamus, and substanti a nigra reticulata. The results show that acute administration of cloz apine or haloperidol are associated with different distribution patter ns of altered cerebral energy metabolism. Clozapine differently from h aloperidol, reduces energy metabolism of the nucleus accumbens and oth er Limbic areas. Haloperidol, but not clozapine (1 or 5 mg/kg), affect s the substantia nigra reticulata. (C) 1997 Elsevier Science B.V.