INTERLEUKIN-1-BETA DOES NOT INCREASE SYNAPTIC INHIBITION IN HIPPOCAMPAL CA3 PYRAMIDAL AND DENTATE GYRUS GRANULE CELLS OF THE RAT IN-VITRO

Authors
ZEISE ML ESPINOZA J MORALES P NALLI A
Citation
Ml. Zeise et al., INTERLEUKIN-1-BETA DOES NOT INCREASE SYNAPTIC INHIBITION IN HIPPOCAMPAL CA3 PYRAMIDAL AND DENTATE GYRUS GRANULE CELLS OF THE RAT IN-VITRO, Brain research, 768(1-2), 1997, pp. 341-344
Citations number
15
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
768
Issue
1-2
Year of publication
1997
Pages
341 - 344
Database
ISI
SICI code
0006-8993(1997)768:1-2<341:IDNISI>2.0.ZU;2-U
Abstract
Effects of interleukin-1 beta (bath-applied; 500 mu M) on rat hippocam pal CA3 pyramidal and dentate granule cells were studied using intrace llular microelectrode recording in vitro. In both cell types membrane input resistance, resting membrane potential and action potential ampl itude remained stable throughout. No change was seen in postsynaptic p otentials in granule cells. After blocking excitatory synaptic transmi ssion in CA3 pyramids interleukin-1 beta was found to consistently dec rease synaptic inhibition by about 30%. (C) 1997 Elsevier Science B.V.