DIAZOXIDE TREATMENT FOR INSULINOMA - A NATIONAL UK SURVEY

A survey of UK patients receiving the drug diazoxide, revealed 40 pati ents with insulinoma on this treatment. Mean age (+/-SD) was 67+/-18 y ears, and 74% were female. Duration of treatment was 7+/-6 years (rang e 1-22). Most (55%) patients were treated with diazoxide because of tu mour non-localisation (including failed previous surgery). Metastatic disease (20%) and poor surgical risk (10%) were other indications. Sid e-effects (notably fluid retention and hirsutism) were common (47%) bu t not troublesome. Treatment was highly effective - 59% were symptom f ree and 38% had only occasional symptoms. Only one patient had frequen t hypoglycaemia despite treatment. We conclude that diazoxide is effec tive in the management of insulinoma. Side-effects are common but not problematic. Treatment should be considered for all patients not cured by surgery, or unsuitable for surgical treatment.